Lappaconitine Hydrobromide

What Is Lappaconitine Hydrobromide?

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Lappaconitine Hydrobromide(LA) is a kind of diterpenoid alkaloid, labaconitine, which is extracted and isolated from the aconitum of ranunculus family. It is the first non-addictive analgesic drug for central nervous system in China. It has the effects of analgesia, antipyretic, detumescence and local anesthesia, and has the characteristics of non-addiction and less adverse reactions. Its analgesic effect is stronger than indomethacin and weaker than morphine. At present, its strong analgesic and immunomodulatory effects are mainly used in the clinical diagnosis and treatment activities of various specialties, and it is widely used in the late analgesia and perioperative analgesia of cancer.

Product Details

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Chemical & Physical Properties

CAS Number	97792-45-5	Density	N/A
Molecular Formula	C32H45BrN2O8	Molecular Weight	665.61
Melting Point	223-226 ℃	Boiling Point	N/A
Solubleness	Soluble in DMSO (a little), methanol (a little)	Test Method	96% by Titration; 98% by HPLC

COA of Lappaconitine Hydrobromide

Assay Determination by Titration and HPLC

Benefits

Analgesic Effect: The analgesic effect of Lappaconitine Hydrobromide is not as good as morphine, but stronger than indomethacin, and it is 7 times the analgesic effect of antipyretic analgesic aminopyrine. LA analgesia starts slowly but lasts a long time and is a common alternative to tramadol. The analgesic effect can be achieved, and there is no obvious toxic reaction.

Anti-inflammatory and Detumescent Effects: Lappaconitine Hydrobromide has obvious inhibitory effect on a variety of inflammation, such as eliminating the swelling of auricle, toe, joint and lower limb, and inhibiting the formation of intrabulbar granuloma. The anti-inflammatory effect of subcutaneous injection of LA 1.5mg /kg can reach 66 times that of aspirin.

Anti-tumor Effect: Lappaconitine Hydrobromide can be used in the treatment of tumor patients, mainly because it can strongly inhibit cancer pain, and in some studies, it has been found that LA also has a certain inhibitory effect on cancer cells, can promote cancer cell apoptosis.

Anti-arrhythmic Effect: By regulating the expression of voltage-dependent sodium/potassium ion channels and related protein genes on channels, small doses of LA can reduce myocardial contractility, raise myocardial excitation threshold, and slow or stop heart beat, which has anti-arrhythmic effect, but large doses can induce arrhythmia.

Applications

Lappaconitine Hydrobromide can play a significant analgesic effect through a variety of administration methods, and this drug is non-addictive, does not cause the risk of teratosis, and does not lead to accumulation of poisoning in the body. In addition, it also exhibits multiple pharmacological effects such as local anesthesia, thermoregulation (cooling), antipyretic, and elimination of swelling. In the treatment of some patients with malignant tumors, the application of Lappaconitine Hydrobromide can actively improve the overall state of patients, which is manifested as the enhancement of appetite, the enhancement of mental state, the enhancement of immune function and the positive changes of blood indicators. Therefore, the drug is mainly widely used to relieve moderate and above degree of pain symptoms.

OEM and ODM Services

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As a leading Lappaconitine Hydrobromide manufacturer and supplier, KINTAI offers comprehensive OEM and ODM services. Leverage our state-of-the-art facilities, research expertise, and commitment to quality for custom formulations tailored to your specifications. Feel free to contact us at info@kintaibio.com.

Our Certifications

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FAQ

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Advantage Of KINTAI

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Parcel and Shipping

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1> 1KG/bag, 10KG/carton,25kg/drum
2> By Express: Door to door; DHL/FEDEX/EMS; 3-4DAYS; Suitable for under 50kg; high cost; easy to pick up the goods
3> By Air: Airport to Airport; 4-5 days; Suitable for more than 50kg; high cost;professional broker needed
4> By Sea: Port to Port; 15-30days; Suitable for more than 500kg; Low cost; professional broker needed

Please contact KINTAI at info@kintaibio.com for your Lappaconitine Hydrobromide needs. We look forward to serving you!

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